Recessively-inherited mutations in " NTE " that substantially reduce its catalytic activity cause a rare form of hereditary spastic paraplegia ( SPG39 ), in which distal parts of long spinal axons degenerate leading to limb weakness and paralysis.
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A mutation in this gene has been reported to be associated with Hereditary spastic paraplegia, however the Pathogenicity of the mutation, which may simply represent a Polymorphism ( biology ), is unclear . [ provided by RefSeq, Mar 2010 ].
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Diseases that can cause foot drop include direct hit to posterolateral neck of fibula, stroke, amyotrophic lateral sclerosis ( ALS or Lou Gehrig's Disease ), muscular dystrophy, Charcot Marie Tooth disease, multiple sclerosis, cerebral palsy, hereditary spastic paraplegia, Guillain Barr?syndrome and Friedreich's ataxia.
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These situations include those who have suffered meningitis, a congenital ( birth-originating ) brain infection, congenital hydrocephalus unrelated to the person's premature birth, a person who has suffered head trauma, or a person with some sort of familial disease ( e . g ., those with hereditary spastic paraplegia are said to not be SDR candidates ).
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