Humans produce about 0.44 g / L hippuric acid per day in their urine, and if the person is exposed to toluene or benzoic acid, it can rise above that level.
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Other investigations showed specific foods, such as cranberries, prunes and plums had unusual effects on urine pH . While these foods provided an alkaline ash in the laboratory, they contain a weak organic acid, hippuric acid, which caused the urine to become more acidic instead.
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Hippuric acid is also known as benzoylglycine and is produced from benzoic acid in two steps : first benzoic acid is converted to benzoyl-CoA by the enzyme benzoyl-CoA synthase; then benzoyl-CoA is converted to hippuric acid by benzoyl-CoA : glycine N-acyltransferase.
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Hippuric acid is also known as benzoylglycine and is produced from benzoic acid in two steps : first benzoic acid is converted to benzoyl-CoA by the enzyme benzoyl-CoA synthase; then benzoyl-CoA is converted to hippuric acid by benzoyl-CoA : glycine N-acyltransferase.
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4-Hydroxybenzoic acid, 3, 4-dihydroxybenzoic acid ( protocatechuic acid ), 3-methoxy-4-hydroxy-hippuric acid and 3-methoxy-4-hydroxybenzoic acid ( vanillic acid ) are the main catechins metabolites found in humans after consumption of green tea infusions.
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In more recent years, studies have suggested the use of urinary benzylmercapturic acid as the best marker for toluene exposure, because : it is not detected in non-exposed subjects; it is more sensitive than hippuric acid at low concentrations; it is not affected by eating or drinking; it can detect toluene exposure down to approximately 15 " o "-cresol.
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