11. Just a callus, heloma in medical parlance, and hyperkeratosis for the generalized condition. 12. The pawpads can be affected causing marked hyperkeratosis ( thickening of the pads with scale ). 13. Hyperkeratosis can also be caused by B-Raf inhibitor drugs such as Vemurafenib and Dabrafenib.14. Most patients had accompanying hyperkeratosis ( thickening of the skin ) of moderate degree on exposed surfaces. 15. On biopsy, hyperkeratosis , epidermal folding, leukocyte infltration, and melanocyte proliferation may be seen. 16. These are small patches of bare, apparently normal skin in the middle of areas of hyperkeratosis . 17. The hyperkeratosis is brown-grey in colour and is most obvious on the arms and legs. 18. The histopathology of fiddler s neck frequently shows hyperkeratosis and acanthosis, along with plugging of follicles. 19. Lymphoedema may develop in many cases accompanied by acral thickening of the skin folds, hyperkeratosis and papillomatosis. 20. In the 1960s and 1970s there were problems with hyperkeratosis , a disease causing corny pads and severe pain.
