Most people with a hypertensive crisis are known to have elevated blood pressure, but additional triggers may have led to a sudden rise.
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If large amounts of tyramine are consumed, they may suffer hypertensive crisis, which can be fatal . ( See a List of foods containing tyramine ).
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Tyramine leads to hypertensive crisis by increasing the release of norepinephrine ( NE ), which causes blood vessels to constrict ( through binding to alpha-1 adrenergic receptors ).
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Other symptoms accompanying a hypertensive crisis may include visual deterioration due to retinopathy, breathlessness due to heart failure, or a general feeling of malaise due to kidney failure.
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People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur ( an example of a drug-food interaction ).
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For example, unusually high or low levels of MAOs in the body have been associated with schizophrenia, hypertensive crisis, and excessive levels of serotonin may lead to serotonin syndrome.
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The most common example, hypertensive crisis, is caused by the ingestion of tyramine, which is found in foods such as aged cheeses, cured meats, tofu and certain red wines.
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It has become widespread practice to give patients the quick-acting pills to place under their tongue during a hypertensive crisis, said the report in the Journal of the American Medical Association.
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When Gorbachev was placed under house arrest during an attempted coup in 1991, his wife suffered what she later described as an " acute hypertensive crisis " that resembled a minor stroke.
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However, if a patient on MAOIs uses recreational quantities of any drug with stimulant effects on the CNS, it can provoke an adrenergic crisis ( along with the inevitable hypertensive crisis ).
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