A study of high-dose combined intramuscular administration of 40 mg estradiol valerate and 250 mg hydroxyprogesterone caproate per week for six months ( described as a " pseudopregnancy " regimen ) in hypogonadal women found that circulating levels of estradiol increased from 27.8 34.8 pg / mL to 3028 3226 pg / mL after three months and to 2491 2552 pg / mL after six months of treatment.
12.
A study of combined high-dose i . m . estradiol valerate and hydroxyprogesterone caproate in peri-and postmenopausal and hypogonadal women ( described as a " pseudopregnancy " regimen ), with specific dosages of 40 mg weekly and 250 mg weekly, respectively, was found to result in serum estradiol levels of 3028 3226 pg / mL after three months and 2491 2552 pg / mL after six months of treatment from a baseline of 27.8 34.8 pg / mL.
13.
A "'gonadotropin-releasing hormone agonist "'( "'GnRH agonist "', "'GnRH A "') is a synthetic peptide modeled after the hypothalamic neurohormone GnRH that interacts with the gonadotropin-releasing hormone receptor to elicit its biologic response, the release of the pituitary hormones LH . However, after the initial " flare " response, continued stimulation with GnRH agonists desensitizes the pituitary gland ( by causing GnRH receptor downregulation ) to GnRH . Pituitary desensitization reduces the secretion of LH and FSH and thus induces a state of hypogonadotropic hypogonadal anovulation, sometimes referred to as pseudomenopause or medical oophorectomy .
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