The protein fragments form abnormal clumps, known as neuronal intranuclear inclusions ( NIIs ), inside nerve cells, and may attract other, normal proteins into the clumps.
12.
In many other protists ( e . g ., ciliates, sporozoans ) and fungi, the centrosomes are intranuclear, and their nuclear envelope also does not disassemble during cell division.
13.
Such injuries damage either an upper motor neuron ( supranuclear ) or the lower motor neuron ( intranuclear ) Damage can be on one or both sides, which will affect symptoms that the damage causes.
14.
Ataxin-3 is the protein that, in the deubiquitinating enzyme function, forms SCA type-1 and 2 DRPLA intranuclear inclusions ( the regular wild-type protein localized to inclusion bodies ).
15.
The SN test is occasionally used for detection and quantitation of humoral antibody for PPV . Neutralization of infectivity is usually confirmed by the absence or reduction either of intranuclear inclusions or fluorescent cells in cultures or of viral hemagglutinin in the culture medium.
16.
This protein binds to and colocalizes with the breast cancer 2 early onset protein ( BRCA2 ) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2 . ( see Figure "'" Homologous recombinational repair of DNA double-strand damage " "').
17.
Immunocytochemistry is a special case of histochemistry that uses selective antibodies against a variety of chemical epitopes of the nervous system to selectively stain particular cell types, axonal fascicles, neuropiles, glial processes or blood vessels, or specific intracytoplasmic or intranuclear proteins and other immunogenetic molecules, e . g ., neurotransmitters.
18.
Infection with WSSV differs from other described penaeid infections Yellowhead virus ( YHV ) and Infectious Hypodermal and Hematopoietic Necrosis virus ( IHHNV ) in the described histological findings as YHV has a reduced tissue specificity, infecting only the intestinal epithelial tissues and IHHNV causes intranuclear occlusions that stain eosinophillic but do not change over the course of the infection.
19.
The first coincidence was that etoposide and cyclosporine were both found and developed on the chemical and biological side by the same groups, those of the present authors and their specific biological effects were discovered by one of us; second, both compounds were approved by the United States Food and Drug Administration on the same day in November 1983, although they had been submitted by different companies; furthermore, both drugs act via an effect on an intranuclear isomerase, topoisomerase II, and peptide " cis-trans-" isomerase, respectively; both compounds are potent immunosuppressants; etoposide as well as cyclosporine are used in the treatment of leukemias or other malignancies; the latter after bone marrow transplantation to prevent graft-versus-host disease, the former also being used in conjunction with bone marrow transplantation; sometimes, the two compounds are used concomitantly, exploiting the capacity of cyclosporine to reduce certain types of multidrug resistance or to modify immunity against tumors cured by etoposide; in the development of both drugs, galenical problems arose, related to poor water solubility and absorption from intestinal tract, and experience gained with etoposide in this area was crucial for overcoming, several years later, difficulties of a similar type with cyclosporine.
20.
". . . there are an astonishing number of coincidences between etoposide and cyclosporine . The first coincidence was that etoposide and cyclosporine were both found and developed on the chemical and biological side by the same groups, those of the present authors and their specific biological effects were discovered by one of us; second, both compounds were approved by the United States Food and Drug Administration on the same day in November 1983, although they had been submitted by different companies; furthermore, both drugs act via an effect on an intranuclear isomerase, topoisomerase II, and peptide cis-trans-isomerase, respectively; both compounds are potent immunosuppressants; etoposide as well as cyclosporin are used in the treatment of leukemias or other malignancies; the latter after bone marrow transplantation to prevent graft-versus-host disease, the former also being used in conjunction with bone marrow transplantation; sometimes, the two compounds are used concomitantly, exploiting the capacity of cyclosporine to reduce certain types of multidrug resistance or to modify immunity against tumors cured by etoposide; in the development of both drugs, galenical problems arose, related to poor water solubility and absorption from intestinal tract, and experience gained with etoposide in this area was crutial for overcoming, several years later, difficulties of a similar type with cyclosporine.
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