11. It has been proposed that the MGAT4A isoenzyme acts as a toggle for developing of type 2 diabetes. 12. However, isoenzyme analysis reveals that it is more closely related to " Rauvolfia tetraphylla L ". 13. About 20 percent of dofetilide is metabolized in the liver via the CYP3A4 isoenzyme of the cytochrome P450 enzyme system. 14. MCPP is metabolized via the CYP2D6 isoenzyme by hydroxylation to p-hydroxy-mCPP ( OH-mCPP ). 15. Hence, this isoenzyme is an important regulator of glycolysis and additional functions in other novel roles that have recently emerged. 16. Finally C9-triazole derivatives of DANA containing an alkoxy group with a nanomolar activity against hNEU4 isoenzyme have been reported. 17. With a 500-fold selectivity for hNEU4, this is the highest reported selectivity for a hNEU isoenzyme to date. 18. An isoenzyme of glycogen phosphorylase exists in the liver sensitive to glucose concentration, as the liver acts as a glucose exporter. 19. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. 20. The majority of flecainide is eliminated by the kidneys, with the remainder metabolized by the cytochrome P450 2D6 isoenzyme in the liver.
