11. However, non-neurological features ( other than lactic acidosis ) are not seen in PDHC deficiency. 12. "' Lactic acidosis "'arises from impairment of gluconeogenesis. 13. However, the use in lactic acidosis is contraindicated. 14. Concurrent therapy with calcium channel blocker may increase risk of low heart rate, and lactic acidosis . 15. Lactic acidosis usually causes a ratio of 1.616. Other metabolic derangements include lactic acidosis and hyperlipidemia. 17. Lactic acidosis is typically the result of an underlying acute or chronic medical condition, medication, or poisoning.18. Most of these cause a lactic acidosis . 19. Because metformin decreases liver uptake of lactate, any condition that may precipitate lactic acidosis is a contraindication. 20. Gastrografin is contraindicated to use along with certain medications that can cause lactic acidosis , such as metformin.
