The 3, 6-diesters of morphine are drugs with more rapid and complete central nervous system penetration due to increased lipid solubility and other structural considerations.
12.
This correlation is true for a wide range of anaesthetics with lipid solubilities ranging over 4-5 orders of magnitude if olive oil is used as the oil phase.
13.
Because of fentanyl's high lipid solubility, its effects are more localized than morphine, and some clinicians prefer to use morphine to get a wider spread of analgesia.
14.
However, in living organisms the free-radical terminating effectiveness of each carotenoid is heavily modified by its lipid solubility, and thus varies with the type of system being protected.
15.
The partial pressure of a gas required to cause a measured degree of impairment correlates well with the lipid solubility of the gas : the greater the solubility, the less partial pressure is needed.
16.
Lorazepam is a different case; its low lipid solubility makes it relatively slowly absorbed by any route other than intravenously, but once injected, it will not get significantly redistributed beyond the vascular space.
17.
Meyer and Overton had discovered the striking correlation between the physical properties of general anaesthetic molecules and their potency : the greater is the lipid solubility of the compound in olive oil the greater is its anaesthetic potency.
18.
Furthermore, the lipid solubility of the nonionized species is slight as shown by its low logP value ( log ( 10 ) of the distribution coefficient of the nonionized form between octanol and water ) of-1.43.
19.
The hypothesis correlates lipid solubility of an anaesthetic agent with potency ( 1 / MAC ) and suggests that onset of anaesthesia occurs when sufficient molecules of the anaesthetic agent have dissolved in the cell's lipid membranes, resulting in anaesthesia.
20.
The distribution of a drug between tissues is dependent on vascular permeability, regional blood flow, cardiac output and perfusion rate of the tissue and the ability of the drug to bind tissue and plasma proteins and its lipid solubility . pH partition plays a major role as well.
How to say lipid solubility in Hindi and what is the meaning of lipid solubility in Hindi? lipid solubility Hindi meaning, translation, pronunciation, synonyms and example sentences are provided by Hindlish.com.
