11. Weak lipophilic properties accumulate in acidic intracellular compartments like lysosomes . 12. Sphingosine is formed via degradation of sphingolipid in the lysosome . 13. Lysosomes degrade waste and toxins with the enzymes they contain.14. Hepcidin ultimately breaks down the transporter protein in the lysosome . 15. A pinched-off coated pit is internalized and degraded by lysosomes . 16. This occurs by diffusion of Ambroxol into lysosomes and lysosomal pH neutralization. 17. GATA4 is regulated through the autophagy-lysosome pathway in eukaryotic cells. 18. Thus the Rag complex recruits mTORC1 to lysosomes to interact with Rheb. 19. The fusion of lysosomes with the phagosome creates a phagolysosome . 3. 20. Lysosomes are organelles that contain hydrolytic enzymes that are used for intracellular digestion.