Macromastia has also been associated with hypercalcemia ( which is thought to be due to excessive production of parathyroid hormone-related protein ) and, rarely, systemic lupus erythematosus and pseudoangiomatous stromal hyperplasia.
12.
Aromatase excess syndrome, an extremely rare condition characterized by marked hyperestrogenism, is associated with precocious breast development and macromastia in females and similarly precocious gynecomastia ( women's breasts ) in males.
13.
When gigantomastia occurs in young women during puberty, the medical condition is known as " juvenile macromastia " or " juvenile gigantomastia " and sometimes as " virginal breast hypertrophy " or " virginal mammary hypertrophy ".
14.
In females, symptoms of AES include isosexual precocity ( precocious puberty with phenotypically-appropriate secondary sexual characteristics ), macromastia ( excessively large breasts ), an enlarged uterus, menstrual irregularities, and, similarly to males, accelerated bone maturation and short final height.
15.
Elevated levels of HGF and, to a lesser extent, IGF-1 ( by 5.4-fold and 1.8-fold, respectively ), in breast stromal tissue, have been found in macromastia, a very rare condition of extremely and excessively large breast size.
16.
Exposure of macromastic breast stromal tissue to non-macromastic breast epithelial tissue was found to cause increased alveolar morphogenesis and epithelial proliferation in the latter . might have the potential to induce macromastia-like breast growth in an exposure-dependent manner . and a study of women with macromastia indicated that there may be a significant association between macromastia and increased risk of breast cancer.
17.
Exposure of macromastic breast stromal tissue to non-macromastic breast epithelial tissue was found to cause increased alveolar morphogenesis and epithelial proliferation in the latter . might have the potential to induce macromastia-like breast growth in an exposure-dependent manner . and a study of women with macromastia indicated that there may be a significant association between macromastia and increased risk of breast cancer.
18.
Exposure of macromastic breast stromal tissue to non-macromastic breast epithelial tissue was found to cause increased alveolar morphogenesis and epithelial proliferation in the latter . might have the potential to induce macromastia-like breast growth in an exposure-dependent manner . and a study of women with macromastia indicated that there may be a significant association between macromastia and increased risk of breast cancer.
19.
Known estrogen-dependent conditions include mastodynia ( breast pain / tenderness ), breast fibroids, mammoplasia, macromastia ( breast hypertrophy ), gynecomastia, breast cancer, melasma, menorrhagia, endometriosis, endometrial hyperplasia, adenomyosis, uterine cancers ( e . g ., endometrial cancer ), and hyperestrogenism in males such as in certain conditions like cirrhosis and Klinefelter's syndrome.
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