Additionally, it has been shown that the interaction between APP and kinesin is specific to the peptide sequence of APP . In a recent experiment involving transport of peptide-conjugated colored COOH moiety of peptides is not sufficient to mediate transport.
12.
If the water table is at or above the surface, then methane transport begins to take place primarily through ebullition and vascular or pressurized plant mediated transport, with high levels of emission occurring during the day from plants that use pressurized ventilation.
13.
Eluxadoline was not found to inhibit BCRP-, BSEP-, MRP2-, OCT1-, OCT2-, OAT1-, OAT3-, or OATP1B3-mediated transport of probe substrates but inhibited the transport of probe substrates of OATP1B1 and P-gp.
14.
As such, PBPK modeling can be used, " inter alia ", to evaluate the involvement of carrier-mediated transport, clearance saturation, enterohepatic recirculation of the parent compound, extra-hepatic / extra-gut elimination; higher " in vivo " solubility than predicted " in vitro "; drug-induced gastric emptying delays; gut loss and regional variation in gut absorption.
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