11. It is also expressed in hematopoietic progenitor cells including erythroblasts, myeloblasts, and megakaryocytes . 12. Immunophenotyping using MoAb to megakaryocyte restricted antigen ( CD41 and CD61 ) may be diagnostic. 13. On the other hand, high platelet concentrations lead to less availability of thrombopoietin to megakaryocytes . 14. The abnormal megakaryocytes stimulate other cells, the fibroblasts, to produce collagen in the bone marrow. 15. P-selectin is constitutively expressed in megakaryocytes ( the precursor of platelets ) and endothelial cells. 16. GATA1 is required for the maturation of red blood cells, megakaryocytes , mast cells and eosinophils. 17. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. 18. LOX expression was also detected in megakaryocytes , or bone marrow cells responsible for the production of platelets. 19. SCF also increases the survival of various hematopoietic progenitor cells, such as megakaryocyte progenitors, in vitro. 20. VIP acts in an autocrine fashion via VPAC 1 1 to inhibit megakaryocyte proliferation and induce proplatelet formation.
