An abnormal metabolism or change in the expression of sulfatide has also been associated with various pathologies, including neuropathologies, such as metachromatic leukodystrophy, Alzheimer's disease, and Parkinson's Disease.
12.
"' Metazym "'is an experimental recombinant enzyme that was studied in patients with late infantile metachromatic leukodystrophy, but found to be ineffective under the conditions of that trial.
13.
Elevated levels of sulfatide are also associated with Metachromatic Leukodystrophy, which leads to the progressive loss of myelin as a result of sulfatide accumulation in the Schwann cells, oligodendrocytes, astrocytes, macrophages and neurons.
14.
White matter degeneration is associated with and makes differential diagnoses out of other adult onset leukodystrophies such as metachromatic leukodystrophy ( MLD ), Krabbe disease ( globoid cell leukodystrophy ), and X-linked adrenoleukodystrophy ( X-ADL ).
15.
"' Metachromatic leukodystrophy "'( "'MLD "', also called "'Arylsulfatase A deficiency "') is a lysosomal storage disease which is commonly listed in the family of leukodystrophies as well as among the sphingolipidoses as it affects the metabolism of sphingolipids.
16.
This discovery assisted other scientists in the elucidation of similar glycolipid storage diseases such as Gaucher's disease and cerebroside-3-sulfate, a lipid found in high concentrations in patients afflicted with Metachromatic leukodystrophy were known to have helped in the later-day therapeutic protocols.
17.
Treatment is still being studied and evaluated, but mice studies indicate that treatments, including gene therapy, cell-based therapies using oligodendrocyte progenitors cells, enzyme replacement therapy, or lentiviral mediated gene therapy may prove to be effective in reducing the effects of Metachromatic Leukodystrophy.
18.
Most of the research so far has been done on five types : ( 1 ) Metachromatic Leukodystrophy ( MLD ), ( 2 ) Krabbe Disease, ( 3 ) X-Linked adrenoleukodystrophy ( ALD ), ( 4 ) Canavan Disease, and ( 5 ) Alexander Disease.
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