11. Combining a diaphragm with a microbicide will likely be a strong option, she said. 12. One solution might be a vaginal microbicide that a woman would apply in anticipation of intercourse. 13. The need for a microbicide is even more urgent because there is no vaccine for HIV. 14. "But even a partially effective microbicide could save millions of lives, " she added. 15. At the highest concentrations of microbicide , five out of five of the animals were protected. 16. An effective microbicide , which must be affordable in poor countries, would be immensely useful. 17. The microbicide initiative is part of a small, overall increase in federal spending on HIV prevention. 18. Now, it is doubtful that trial will continue, until a new microbicide candidate is found. 19. VOICE is the first efficacy trial of both pre-exposure prophylaxis and vaginal microbicide HIV prevention. 20. Daunting, but not insurmountable, " said Joseph Perriens, UNAIDS manager of the microbicide effort.