11. These metabolites are also found after oxidation with rat hepatic microsomes " in vitro ". 12. Like other formamidines amitraz inhibits the synthesis of prostaglandin E2 from arachidonic acid by bovine seminal vesicle microsomes . 13. Emodin was mutagenic in the Salmonella / microsome assay, but gave inconsistent results in gene mutation assays. 14. ALD3H2 is expressed in the human liver and has been found to localize the microsome fraction inside the cell. 15. RGPR-p117 is present in the plasma membranes, cytoplasm, mitochondria, microsomes and nucleus of the cells. 16. A portion of the atomic sulfur formed in this reaction covalently binds to macromolecules of the liver and lung microsomes . 17. No hydroxylated metabolites were identified after incubation with rat liver microsomes ( S9 ) or in rat urine following oral dosing. 18. It also tested positive in a " Salmonella " / mammalian microsome assay and was shown to be genotoxic. 19. The proposed metabolic pathways of aconitine in human liver microsomes and the CYPs involved to it are summarized in the table above. 20. The first and most important step of metabolism of chlorfenvinphos in humans is accomplished by the enzyme cytochrome P450 in liver microsomes .
