While in prokaryotic systems the basal transcription state can be thought of as nonrestrictive ( that is, on in the absence of modifying factors ), eukaryotes have a restrictive basal state which requires the recruitment of other factors in order to generate RNA transcripts.
12.
It has been found that for stochastic radiation risk ( defined as " probability " of cancer induction and genetic effects ) consideration must be given to the type of radiation and the sensitivity of the irradiated tissues, which requires the use of modifying factors.
13.
The significant intrafamilial variability observed in the severity of renal and extrarenal manifestations points to genetic and environmental modifying factors that may influence the outcome of ADPKD, and results of an analysis of the variability in renal function between monozygotic twins and siblings support the role of genetic modifiers in this disease.
14.
Before the fourth edition, skill and ability checks worked as follows : all actions in the game, from the use of skills to making attacks in combat, are first given a target number that reflects the difficulty of the action which is then raised or lowered by various modifying factors, such as environmental conditions, the condition of the character, the use of mechanical aids, and so forth.
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