Osteoclasts are large, multinucleated cells which " eat up " old, stressed, broken or decaying bone in a process known as bone resorption.
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The characteristic morphological element is the tuberculous granuloma ( caseating tubercule ) : giant multinucleated cells ( Langhans cells ), surrounded by epithelioid cells aggregates, T cell lymphocytes and few fibroblasts.
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HERV-W s main gene expression is ERVWE-1 which is a highly fusogenic env glycoprotein also called syncytin-1 because it induces the formation of syncytia ( multinucleated cells ).
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In the siphonous green algae Bryopsidales and some Dasycladales the entire thallus is a single multinucleate cell, which can be many meters across ( e . g . " Caulerpa " ).
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Pathomorphologic study of tissue sampling revealed : polymorphism of spiny epithelial cells has progressed into atypism; increased mitosis; giant and multinucleate cells; acanthosis; hyperkeratosis and parakeratosis; basal membrane and basal layer are retained.
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Some of the more well known include the lesions containing pseudo-sarcomatous components : spindle cell carcinoma ( containing elongated cells resembling connective tissue cancers ), giant cell carcinoma ( containing huge, bizarre, multinucleated cells ), and sarcomatoid carcinoma ( mixtures of spindle and giant cell carcinoma ).
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