11. This is in contrast with myelofibrosis that develops secondary to polycythemia vera or essential thrombocythaemia. 12. Older terms include " myelofibrosis with myeloid metaplasia " and " agnogenic myeloid metaplasia ". 13. Myelofibrosis is an extremely rare and fatal disease afflicting some 3, 000 people a year.14. A marrow aspirate is difficult to obtain in many cases because of variable degree of myelofibrosis . 15. He died of myelofibrosis and was survived by his daughter Julia and mother Rose Apter Weinberg. 16. He died in 2012 after a 5-year struggle with the blood disorder autoimmune myelofibrosis . 17. Alderson died at his home in Marina Del Rey, California, due to complications from myelofibrosis . 18. The V617F mutation to the JAK2 protein is found in approximately half of individuals with primary myelofibrosis . 19. Primary myelofibrosis can begin with a blood picture similar to that found in polycythemia vera or chronic myelogenous leukemia. 20. In primary myelofibrosis , progressive scarring, or fibrosis, of the bone marrow occurs, for the reasons outlined above.
