The homology of biomineralization pathways is underlined by a remarkable experiment whereby the nacreous layer of a molluscan shell was implanted into a human tooth, and rather than experiencing an immune response, the molluscan nacre was incorporated into the host bone matrix.
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In oysters and potentially most molluscs, the nacreous layer has an organic framework of the protein MSI60, which has a structure a little like spider silk and forms sheets; Aspartic acid, which can make up up to 50 % of shell framework proteins, is most abundant in calcitic layers, and also heavily present in aragonitic layers.
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