11. The embryonic remnants of Rathke s pouch may undergo neoplastic change called a craniopharyngioma. 12. The causes are varied, and may be inflammatory, degenerative, or neoplastic . 13. Tumors may be caused by conditions other than an overgrowth of neoplastic cells, however. 14. Acquired Horner syndrome may result after trauma, neoplastic insult, or even vascular disease. 15. EIN cells are already neoplastic , demonstrating a monoclonal growth pattern and clonally distributed mutations. 16. PLK1 has also been linked to known pathways that are altered during the neoplastic transformation. 17. Nuclear atypia can be seen in reactive changes, pre-neoplastic changes and malignancy. 18. The unique disease principle was first described in neoplastic diseases as the unique tumor principle. 19. Likewise, epigenetic alterations present in tumors may have occurred in pre-neoplastic field defects. 20. In most cases of malignant disease complicated by effusion, neoplastic cells can be easily recognized.
