There are many types of regional anesthesia either by injecting into the tissue itself, a vein that feeds the area or around a nerve trunk that supplies sensation to the area.
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Alfred Goldscheider ( 1884 ) confirmed the existence of distinct heat and cold sensors, by evoking heat and cold sensations using a fine needle to penetrate to and electrically stimulate different nerve trunks, bypassing their receptors.
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Rapid spreading of the pain, bilateral involvement or simultaneous participation with other major nerve trunks ( such as Painful Tic Convulsif of nerves V & VII or occurrence of symptoms in the V and IX nerves ) may suggest a systemic cause.
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There is some research investigating the ability of new axons to grow into the Organ of Corti; Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk : growth of processes into the organ of Corti, Auditory hair cell explant co-cultures promote the differentiation of stem cells into bipolar neurons .-- JWSchmidt 14 : 30, 20 December 2006 ( UTC)
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