It was found that increased hippocampal neurofibrillary tangles and higher neuritic plaque density ( in the superior temporal gyrus, orbitofrontal gyrus, and the inferior parietal cortex ) were associated with increased severity of dementia.
12.
Along with these biological factors, when the patient also had the apolipoprotein E ( ApoE4 ) allele ( a known genetic risk factor for Alzheimer's disease ), the neuritic plaques increased although the hippocampal neurofibrillary tangles did not.
13.
These fibrils deposit outside neurons in dense formations known as senile plaques or neuritic plaques, in less dense aggregates as " diffuse plaques ", and sometimes in the walls of small blood vessels in the brain in a process called amyloid angiopathy or congophilic angiopathy.
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