If the patient is under general anesthesia, the depth of the anesthesia can affect the outcome because if the levels of muscle relaxation are too high due to neuromuscular blocking drugs, then the results from the mapping can be incorrect.
12.
The use of extrinsically administered cysteine to deliberately accelerate reversal of the pharmacological effect of fumarate " bis "-onium neuromuscular blocking drugs ( RV002 [ formerly known as AV002 ], CW002 and CW011 ) is being investigated currently.
13.
Both of these classes of neuromuscular blocking drugs are structurally similar to acetylcholine, the endogenous ligand, in many cases containing two acetylcholine molecules linked end-to-end by a rigid carbon ring system, as in pancuronium ( a nondepolarizing agent ).
14.
The singular distinguishing clinical feature of gantacurium from any other non-depolarizing neuromuscular blocking drug clinically tested is that it has the desired duality of a rapid onset and an ultrashort duration of action even when administered at 3 4 times the ED 95 doses.
15.
Again, however, the untimely intervening merger between Burroughs Wellcome Co . and its rival Glaxo Inc . to form the now non-existent GlaxoWellcome Inc . during 1995 resulted in even further delays to progress in optimizing the halosuccinate and halofumarate series of neuromuscular blocking drugs.
16.
There is considered to be a risk of allergic reaction to the drug in some patients ( particularly those with asthma ), but a similar incidence of allergic reactions has been observed by using other members of the same drug class ( non-depolarizing neuromuscular blocking drugs ).
17.
With the exception of one other clinically tested agent, BW785U77, no other " clinically " administered neuromuscular blocking drug has matched this feat to date : all other non-depolarizing neuromuscular blocking drugs clinically administered at equivalent doses most certainly would result in a medium or long duration of action albeit with a rapid onset of paralyzing effect.
18.
With the exception of one other clinically tested agent, BW785U77, no other " clinically " administered neuromuscular blocking drug has matched this feat to date : all other non-depolarizing neuromuscular blocking drugs clinically administered at equivalent doses most certainly would result in a medium or long duration of action albeit with a rapid onset of paralyzing effect.
19.
Indeed, the idea of exploring asymmetric tetrahydroisoquinolinium esters had already been seeded with parallel and earlier syntheses of another series of asymmetric potential neuromuscular blocking agents, although the original concept for asymmetricity in the design of new neuromuscular blocking drugs dates back to 1962 with reported combinations of the respective halves of laudexium and succinylcholine ( suxamethonium ) modeled, presumably, on the asymmetric structure of the prototypical neuromuscular blocking agent " d "-tubocurarine that made its entry into anesthetic practice on 23 January 1942, at the Montreal Homeopathic Hospital.
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