11. This enzyme participates in nicotinate and nicotinamide metabolism. 12. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. 13. Nicotinamide riboside supplementation in mice has also been shown to activate the UPR mt.14. By converting nicotinamide to niacin, nicotinamide is removed, inhibiting the activity of Sir2. 15. By converting nicotinamide to niacin, nicotinamide is removed, inhibiting the activity of Sir2. 16. The cofactor, nicotinamide D-ribonucleotide. 17. Thus, the two products are asparagusate, nicotinamide adenine dinucleotide, and hydrogen ion. 18. The novel fatty acid composition was freed though a nicotinamide adenine dinucleotide phosphate containing solution. 19. This binding increases the enzyme's affinity for nicotinamide adenine dinucleotide ( NAD + ). 20. In Clostridium, glucose is broken down into pyruvate and nicotinamide adenine dinucleotide ( NADH ).