Fruton studied the chemistry of nitrogen mustards.
12.
Interstrand cross links are caused by chemicals such as nitrogen mustard and psoralen which create cytotoxic lesions.
13.
While at Yale, Goodman and Gilman were assigned a government contract in nitrogen mustard research in 1942.
14.
With an acceptable therapeutic index in humans, nitrogen mustards were first introduced in the clinic in 1946.
15.
This chemist was unable however to produce the nitrogen mustard or binary mustard as the group had wanted.
16.
The subtypes of alkylating agents are the nitrogen mustards, nitrosoureas, tetrazines, aziridines, cisplatins and derivatives, and non-classical alkylating agents.
17.
LS-1727 is a nitrogen mustard ester of nandrolone that was developed as an alkylating antineoplastic agent but was never marketed.
18.
Due to its use in previous studies, the "'nitrogen mustard "'known as " HN2 " became the first chemotherapy drug mustine.
19.
PR-104A is in turn metabolised to reactive nitrogen mustard DNA crosslinking agents in hypoxic tissues such as found in solid tumours.
20.
The era of cancer chemotherapy began in the 1940s with the first use of nitrogen mustards and folic acid antagonist drugs.
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