11. Nucleophilic substitutions can be accompanied by an allylic rearrangement as seen in reactions such as the Ferrier rearrangement.12. The azide anion behaves as a nucleophile; it undergoes nucleophilic substitution for both aliphatic and aromatic systems. 13. The dislodged chlorine has to resort to nucleophilic attack from the rear as in a regular nucleophilic substitution . 14. During his study of alkyl halides, Ingold found evidence for two possible reaction mechanisms for nucleophilic substitution reactions. 15. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of reductive coupling, and nucleophilic substitution . 16. These substitutions can be produced by two different mechanisms categorized at : unimolecular nucleophilic substitution ( S N 2 ). 17. Both are bases, hydroxide being the stronger base, so you might get elimination reactions competing with nucleophilic substitution . 18. On the other hand, aryl fluorides, e . g . fluoroanilines and fluorophenols, often undergo nucleophilic substitution efficiently. 19. In addition to electrophilic aromatic addition, resorcinol ( and other poly-ols ) undergo nucleophilic substitution via the enone form. 20. They can react with carboxylic acids to form ester compounds, and they can ( if activated first ) undergo nucleophilic substitution reactions.
