Although the homozygous Brn3a null mutation is lethal at birth in mice, Brn3a null heterozygotes have no known phenotype . i . e . the Brn3a null mutation is completely recessive.
12.
Although the homozygous Brn3a null mutation is lethal at birth in mice, Brn3a null heterozygotes have no known phenotype . i . e . the Brn3a null mutation is completely recessive.
13.
Transgenic mice homozygous for a null mutation of the " JUP " gene die around embryonic day 12 from substantial defects in adherens junctions and a lack of functional desmosomes in the heart.
14.
"Clock " mutant organisms can either possess a null mutation or an antimorphic allele at the " Clock " locus that codes for an antagonist to the wild-type protein.
15.
In " Mitotic cell growth and spore germination are not compromised when these genes are deleted, but diploids that are homozygous for a SAT-1 null mutation exhibit a decrease in sporulation efficiency.
16.
GAP43 has been termed a'growth'or'plasticity'protein because it is expressed at high levels in presynaptic terminal, its null mutation leading to death within days after birth due to axon pathfinding defects.
17.
But null mutation of coronin in " D . discoideum " resulted in impaired cytokinesis, and many actin mediated processes like endocytosis, cell motility etc . Later on, the protein was identified in many eukaryotic cells.
18.
From studies with ztl-1 mutants, which have a single missense mutation in the kelch domain of the protein and effectively cause a ztl null mutation, TOC1 protein has been found to be stabilized and TOC1 cycling largely eliminated.
19.
In 10 20 % of endometrial cancers, mostly Grade 3 ( the highest PTEN . In 20 % of endometrial hyperplasias and 50 % of endometrioid cancers, PTEN suffers a loss-of-function mutation or a null mutation, making it less effective or completely ineffective.
20.
Zinc finger protein 318 ( ZFP318 ) has a role in the promotion of IgD expression and controlling the alternative splicing of the long pre-mRNA . In immature B cells that mainly express the ? transcript, there is no ZFP318 expression, but in mature B cells with dual IgM and IgD expression, both ? and ? transcript is made and ZFP318 is expressed . found in mice that null mutations in ZFP318 resulted in no IgD expression.
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