The eye begins to develop as a pair of optic vesicles on each side of the forebrain at the end of the 4th week of pregnancy.
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Optic vesicles are outgrowings of the brain which make contact with the surface ectoderm and this contact induces changes necessary for further development of the eye.
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Its expression is first observed in stage 25 in Xenopus embryos in the developing optic vesicles and in nascent motor and interneurons of the spinal cord.
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For example, Foxg1, also called Brain-Factor 1, and Foxd1, also called Brain Factor 2, are winged-helix transcription factors that are expressed in the nasal and temporal optic cups asn the optic vesicles being to evaginate from the neural tube.
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