11. Thus cementoblasts resemble bone-forming osteoblasts but differ functionally and histologically. 12. Thus, osteoblast activity is self regulated by a negative feedback system. 13. Along with secreting collagen and proteins, Osteoblasts also deposit calcium phosphate. 14. MSCs can differentiate into osteoblasts , chondrocytes, and adipocytes. 15. Expression in adults is bone specific and highest in osteoblasts . 16. Then osteoblasts deposit compact bone within the resorption pit. 17. Osteoblasts separate bone from the extracellular fluid by tight junctions by regulated transport.18. Bones are made of cells called osteoclasts and osteoblasts . 19. Second, there is cellular differentiation of mesenchymal cells into osteoblasts or fibroblasts. 20. These collagen fibers are used as a framework for the osteoblasts 'work.