11. Plasmin has been shown to interact with Thrombospondin 1, Alpha 2-antiplasmin and IGFBP3.12. Plasmin initiates fibrinolysis by degrading fibrin.13. Serum proteinases such as plasmin catalyze the release of active TGF-? from the complex. 14. The release of the growth factor from heparin is mediated by cell-activated plasmin degradation. 15. In vitro, plasmin can activate pro-MMP7 to 50 % of its full activity. 16. An enzyme called plasmin contained in the endometrium tends to inhibit the blood from clotting. 17. Simultaneously, excess circulating thrombin assists in the conversion of plasminogen to plasmin , resulting in fibrinolysis. 18. Plasmin mediates the degradation of the extracellular matrix either by itself or in conjunction with matrix metalloproteinases.19. Plasmin cleaves at the site recognizable to trypsin, is considered as the most possible physiological activator.20. This drug is made by transgenic bacteria and it converts plasminogen into the clot-dissolving enzyme plasmin .
