11. It is also capable of generating plasmin from plasminogen : 12. However, the use of recombinant tissue plasminogen activator is not without risks. 13. Angiostatin is part of a larger protein called plasminogen , which helps blood clot. 14. TPA, or tissue plasminogen activator, is the only federally approved drug treatment. 15. SuPAR, soluble urokinase-type plasminogen activator receptor, ( NCBI Accession no. 16. PAI-1, however, is the main inhibitor of the plasminogen activators. 17. Tissue-type plasminogen 's presence has been recorded during the cortical reaction. 18. Plasminogen does nothing to stop tumor growth.19. The research looked at tissue plasminogen activator, TPA, an enzyme that dissolves clots. 20. Type II plasminogen is preferentially recruited to the cell surface over the type I glycoform.