11. TPA, short for tissue plasminogen activator , is a genetically engineered version of a natural clot-dissolving protein. 12. Barr used reteplase, a newer version of the better-known clot-busting drug TPA, or tissue plasminogen activator . 13. Currently available thrombolytic agents include streptokinase, urokinase, and alteplase ( recombinant tissue plasminogen activator , rtPA ). 14. The proteins are uPA-- short for urokinase-type plasminogen activator -- and its natural inhibitor, known as PAI-1. 15. Activase is a genetically engineered version of the naturally occurring hormone tissue plasminogen activator , or t-PA. 16. Plasminogen activator inhibitor-1, an inhibitor of fibrinolysis, is present in higher levels in people with obesity.17. It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator . 18. The somatomedin B domain of vitronectin binds to plasminogen activator inhibitor-1 ( PAI-1 ), and stabilizes it. 19. Urokinase plasminogen activator receptor ( uPAR ) is a cofactor for plasminogen activation by urokinase plasminogen activator. 20. Urokinase plasminogen activator receptor ( uPAR ) is a cofactor for plasminogen activation by urokinase plasminogen activator .
