In solid state chemistry and the bio-pharmaceutical industry, Raman spectroscopy can be used to not only identify ( ID ) active pharmaceutical ingredients ( APIs ), but in the case of multiple polymorphic forms, it can also be used to identify the polymorphic form of the API . For example, there are 4 different polymorphic forms of the API ( aztreonam ) in Cayston, a drug marketed by Gilead Sciences for cystic fibrosis.
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In solid state chemistry and the bio-pharmaceutical industry, Raman spectroscopy can be used to not only identify ( ID ) active pharmaceutical ingredients ( APIs ), but in the case of multiple polymorphic forms, it can also be used to identify the polymorphic form of the API . For example, there are 4 different polymorphic forms of the API ( aztreonam ) in Cayston, a drug marketed by Gilead Sciences for cystic fibrosis.
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Ethyl cyanoacetate is a colorless liquid, it boils at atmospheric pressure at 209 �C . The vapor pressure follows the Antoine equation log 10 ( P ) = A " ( B / ( T + C ) ) ( P in bar, T in K ) with A = 7.46724, B = 3693.663 and C = 16.138 in the temperature range from 341 to 479 K In solid phase, two polymorphic forms can occur.
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Competitors in turn patented hydrates of the drug with varying water content, which were described with only basic techniques such as infrared spectroscopy and XRPD, a practice criticised in one review because these techniques at the most suggest a different crystal structure but are unable to specify one; however, given the recent advances in XRPD, it is perfectly feasible to obtain the structure of a polymorph of a drug, even if there is no single crystal available for that polymorphic form.
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In rule [ \ mathtt { Abs } ], the value variable of the parameter of the function \ lambda x . e is added to the context with a monomorphic type through the premise \ Gamma, \ x : \ tau \ vdash _ D e : \ tau', while in the rule [ \ mathtt { Let } ], the variable enters the environment in polymorphic form \ Gamma, \ x : \ sigma \ vdash _ D e _ 1 : \ tau.
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