11. Bub1, Rae1 has more promiscuous binding as it binds both the nuclear pore complex and Bub1. 12. The entry and exit of large molecules from the nucleus is tightly controlled by the nuclear pore complexes . 13. If the cell is synthesizing DNA each pore complex needs to transport about 100 histone molecules per minute. 14. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex . 15. Aladin is a component of the nuclear pore complex , to which it is attached by nucleoporin NDC1. 16. He has also proposed an analytical model to elucidate the mechanism of protein transport across the nuclear pore complex . 17. This is because it interacts with both RNA-binding adapter proteins and components of the nuclear pore complex . 18. Small particles ( < ~ 40 kDa ) are able to pass through the nuclear pore complex by passive diffusion. 19. This is followed by an energy-dependent translocation of the nuclear protein through the channel of the pore complex . 20. FG-nucleoporins also contain a globular portion that serves as an anchor for attachment to the nuclear pore complex .
