Recent research has suggested a role for retinoids in cutaneous adverse effects for a variety of drugs including the antimalarial drug proguanil.
12.
Atovaquone alone is not indicated for treatment or prevention of malaria as monotherapy ( i . e ., without proguanil ).
13.
The addition of proguanil has shown to reduce resistance to atovaquone and increase the ability of atovaquone to trigger a mitochondrial apoptotic cascade.
14.
Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi.
15.
The combination of atovaquone and proguanil to treat malaria was patented by Glaxo Wellcome in 1999, and its patent protection expired in 2013.
16.
It combines two medications : atovaquone, used to treat lung infections in immune-compromised patients, and proguanil, an old malaria therapy.
17.
Roughly 67 % of participants in the mefloquine arm reported greater than or equal to one adverse event, vs 71 % in the atovaquone-proguanil arm.
18.
In the mefloquine arm, 5 % of the users reported severe events requiring medical attention, vs 1.2 % in the atovaquone-proguanil arm.
19.
This is commonly referred to as collapse of the mitochondrial membrane potential . Proguanil lowers the effective concentration of atovaquone needed to increase permeability of the mitochondrial membrane.
20.
Lastly, some drugs, such as furazolidone, furoxone, benomyl, fumagillin, proguanil and clamoxyquine, have been shown to impede spore development, which reduces infection rates.
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