11. Propranolol is an aryloxypropanolamine, which are more potent ?-blockers than arylethanolamines.12. Propranolol appears to ease withdrawal symptoms by diminishing the anxiety-causing effects of adrenaline.13. Sir James Black discovered beta blockers propranolol ( Inderal ) at Alderley Park in 1962. 14. Use of a beta blocker such as propranolol is contraindicated in Prinzmetal's angina. 15. Other beta-blockers, such as propranolol , persistently reduce cardiac output during exercise. 16. Examples of drugs with a high hepatic extraction ratio include propranolol , opiates, and lignocaine 17. Propranolol has subsequently become the first-line systemic medical therapy for treatment of these lesions.18. Preliminary evidence suggests that propranolol is most effective at low doses ( 10 20 mg ). 19. Its potency is similar to propranolol . 20. Introduced in 1976, atenolol was developed as a replacement for propranolol in the treatment of hypertension.
