Other products of vitamin B 6 metabolism excreted in the urine when high doses of the vitamin have been given include pyridoxal, pyridoxamine, and pyridoxine and their phosphates.
12.
Transaminases require the coenzyme pyridoxal-phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid.
13.
On January 12, 2009, the FDA ruled that products containing pyridoxamine are excluded from the definition of dietary supplements as defined by the Dietary Supplement Health and Education Act of 1994.
14.
Water attacks the alpha carbon of the imine of PLP-TYR and through acyl substitution kicks off the nitrogen of PLP and forming pyridoxamine phosphate ( PMP ) and 4-hydroxyphenylpyruvate.
15.
ALT ( and all aminotransferases ) require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid.
16.
Compounds that have been found to inhibit AGE formation in the laboratory include Vitamin C, benfotiamine, pyridoxamine, alpha-lipoic acid, taurine, pimagedine, aspirin, carnosine, metformin, pioglitazone, and pentoxifylline.
17.
In humans, the pyridoxine 5-phosphate oxidase enzyme exhibits a low catalytic rate constant of 0.2 sec-1, with low Km values for both pyridoxine 5'phosphate and pyridoxamine 5'- phosphate.
18.
Pyridoxamine is hypothesized to trap intermediates in the formation of Amadori products released from glycated proteins, possibly preventing the breakdown of glycated proteins by disrupting the catalysis of this process through disruptive interactions with the metal ions crucial to the redox reaction.
19.
Pyridoxine 5-phosphate oxidase catalyzes several reactions; the two most important are the deamination of pyridoxamine-5'- phosphate and the deamination of pyridoxine 5-phosphate, both of which are key intermediates in the metabolism of B 6.
20.
One research study found that pyridoxamine specifically reacts with the carbonyl group in Amadori products, but inhibition of post-Amadori reactions ( that can lead to advanced glycation endproducts ) is due in much greater part to the metal chelation effects of pyridoxamine.
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