11. Pyridoxine , also known as GABA . Thus GABA synthesis can continue and symptoms are relieved.12. Pyridoxine is a water-soluble vitamin and is generally recognized as having no adverse effects.13. Treatment with folic acid, thiamine, and pyridoxine may enhance the breakdown of toxic metabolites. 14. Pyridoxine ( vitamin B 6 ) is a precursor of coenzymes including vitamin B 6 functions.15. The pyridine ring occurs in many important compounds, including azines and the vitamins niacin and pyridoxine . 16. Two reported cases of neuropathy with pyridoxine treatment of 24 and 40 mg / day may have been coincidental. 17. Simply adding high dose pyridoxine to the regimen once neuropathy has occurred will not stop the neuropathy from progressing. 18. Studies have demonstrated the convulsions caused by MPN can be prevented or treated successfully with pyridoxine ( vitamin B6 ). 19. Adjunct agents including thiamine and pyridoxine are often given, because they may help prevent the formation of oxalic acid. 20. Along with AKT-4, many patients may need supplements for Vitamin B6 ( Pyridoxine ) and Folic Acid.