11. Salt crystals were mixed with pyrimethamine so as to provide a 0.07 % pyrimethamine salt. 12. Therefore, basic drugs ( like bupivacaine, pyrimethamine ) are more charged inside the cell than outside. 13. The report also showed that Isotab contained Pyrimethamine which is in fact used for the treatment of malaria. 14. Artesunate + sulfadoxine / pyrimethamine should be avoided in the newborns due to sulfadoxine / pyrmethamine effects on bilirubin. 15. Resistance is also developing to sulfadoxine-pyrimethamine , the drug routinely used to replace chloroquine, the report said. 16. Resistance is also developing to sulfadoxine-pyrimethamine , the drug now commonly used to replace chloroquine, the report said. 17. "Plasmodium " have developed resistance against antifolate combination drugs, the most commonly used being sulfadoxine and pyrimethamine . 18. It may be prescribed in the treatment of toxoplasmosis retinitis, in combination with the folic acid antagonists pyrimethamine and sulfadiazine. 19. In addition, in 60 villages, MDA with sulfalene / pyrimethamine was given at 10 week intervals for two years. 20. Within three and a half months of the onset of the campaign, clinically significant levels of pyrimethamine resistance were reported.