However, the high temperature of the calcination gave less-reactive oxide, and the use of hydrochloric acid, which can cause reduction of quadrivalent cerium, led to an incomplete separation of cerium and the trivalent lanthanides.
12.
The quadrivalent influenza vaccine licensed by the CDC is currently designed to protect against both co-circulating lineages and has been shown to have greater effectiveness in prevention of influenza caused by influenza B virus than the previous trivalent vaccine.
13.
Both Gardasil ( a quadrivalent prophylactic HPV vaccine licensed in 2006 ) and Cervarix ( a bivalent prophylactic vaccine license in the EU in 2007 and USA in 2009 ) contain virus-like particles assembled from L1 protein, an approach successful against BPV, and both vaccines induce sustained immunity.
14.
In October 2010, the Australian regulatory agency, the Therapeutic Goods Administration, extended the registration of the quadrivalent vaccine ( Gardasil ) to include use in males aged 9 through 26 years of age, for the prevention of external genital lesions and infection with HPV types 6, 11, 16 and 18.
15.
A study with 9vHPV, a 9-valent HPV vaccine that protects against HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58, came to the result that the rate of high-grade cervical, vulvar, or vaginal disease was the same as when using a quadrivalent HPV vaccine.
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