It is a quinazoline-based pan-HER inhibitor that blocks signaling through HER tyrosine-kinase receptors including HER1 ( erbB1; EGFR ), HER2 ( erbB2 ), and HER4 ( erbB4 ).
12.
Of discontinued clinical-stage molecules, RG3039, also known as Quinazoline495, was a proprietary quinazoline derivative developed by Repligen and licensed to Pfizer in March 2014 which was discontinued shortly after, having only completed phase I trials.
13.
"' Doxazosin mesylate "', a quinazoline compound sold by Pfizer under the brand names "'Cardura "'and "'Carduran "', is an high blood pressure and urinary retention associated with benign prostatic hyperplasia ( BPH ).
14.
His patents were related to basically substituted heterocyclic compounds, e . g . 2, 3-benzotriazine-4 ( 3H )-one derivatives ( coumarin ), and basically substituted 1H, 3H )-quinazoline-2-thion-4-one derivatives, having excellent coronary dilator properties.
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