Serpins have a complex structure, a key component of which is the reactive site loop, RSL . Inhibitory serpins transition between a stress and relaxed stage.
12.
This conformational flexibility indicates an equilibrium may exist within the complex between a P14 P15 reactive site loop inserted antithrombin conformation and a P14 P15 reactive site loop expelled conformation.
13.
This conformational flexibility indicates an equilibrium may exist within the complex between a P14 P15 reactive site loop inserted antithrombin conformation and a P14 P15 reactive site loop expelled conformation.
14.
The reactive site of antistasin formed by Arg-34 and Val-35 in the N-terminal domain suits the binding site of FXa, most likely the S1 pocket.
15.
Similarly, precursors with three methyl groups can be used to limit molecular weight, since each such molecule has only one reactive site and so forms the end of a siloxane chain.
16.
When an antigen enters the blood or tissue fluids it is assumed that it will attach to the surface of any lymphocyte carrying reactive sites which correspond to one of its antigenic determinants.
17.
It is thought that the increased flexibility given to the reactive site loop as a result of the hinge region conformational change is a key factor in influencing increased Factor IXa and Xa inhibition.
18.
In a similar manner, precursors with three methyl groups can be used to limit molecular weight, since each such molecule has only one reactive site and so forms the end of a siloxane chain.
19.
In the structures shown in Figure 5 the C-terminal portion ( P'side ) of the reactive site loop is in an extended conformation when compared with other un-activated or heparin activated antithrombin structures.
20.
The photochemically reactive sites in psoralens are located at each of the carbon-carbon double bonds in the furan ring ( the five-member ring ) and the pyrone ring ( the six-member ring ).
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