As of July, the number of suspected cases of red cell aplasia caused by Eprex had grown to 160, and answers remained elusive.
12.
Most of the reported pure red cell aplasia cases, as of June, have been associated with subcutaneous administration, the typical method of use in most countries.
13.
"' Paul Kaznelson "'( 1898 & ndash; 1959 ) was a Polish-born Czech scientist credited with describing the first case of pure red cell aplasia.
14.
In the patients with red cell aplasia, Mayeux found that antibodies treated the drug as a foreign protein _ and then did the same to the patient's natural EPO as well.
15.
In the meantime, Johnson & Johnson began to note red cell aplasia in patients taking competing products, including NeoRecormon, made by Roche, and Epogen, made by Amgen.
16.
About 175 people taking Eprex between 1998 and this April contracted a disease called pure red cell aplasia, according to a paper being published in The New England Journal of Medicine on Thursday.
17.
Johnson & Johnson contends that the handful of cases of red cell aplasia in users of its competitors'drugs are evidence that the problem, whatever it is, goes beyond Eprex.
18.
Examples of adverse ADA responses include autoimmune thrombocytopenia ( ITP ) following exposure to recombinant thrombopoietin, and pure red cell aplasia, which was associated with a particular formulation of erythropoietin ( Eprex ).
19.
A reason for this speculation is that while there have been 141 suspected cases of red cell aplasia in Eprex users, only a handful of cases have appeared in people using the equivalent drug in the United States.
20.
A patient in her 60s had developed pure red cell aplasia, in which the body's germ-fighting defenses go haywire and attack its own bone marrow, leaving her severely anemic and facing a lifetime of transfusions to survive.
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