11. Statins inhibit HMG-CoA reductase within the mevalonate pathway. 12. An oxido-reductase pathway is present in eukaryotic microorganisms. 13. Thioredoxins act as electron donors to peroxidases and ribonucleotide reductase . 14. Another target of gemcitabine is the enzyme ribonucleotide reductase ( RNR ). 15. When zinc is bound NADPH-thioredoxin reductase -thioredoxin redox system. 16. The activity of glutathione reductase is used as indicator for oxidative stress. 17. The nitrate reductase of higher plants is a cytosolic protein. 18. As trimethoprim, brodimoprim is a selective inhibitor of bacterial dihydrofolate reductase . 19. 12-oxophytodienoate reductase ( OPR3 ) dimerized to itself. 20. The majority of antifolates work by inhibiting dihydrofolate reductase ( DHFR ).