4-Fluoromethylphenidate was studied further along with other analogues of ( ?)-threo-methylphenidate ( TMP ) to assess their potential as anti-cocaine medications . 4F-MPH was reported as having an ED 50 mg / kg of 0.26 ( 0.18 0.36 ) and a relative potency of 3.33 to Methylphenidate.
12.
In addition to CysLTR1, GPR99 ( also termed the oxoglutarate receptor or, sometimes, CysLTR3 ) appears to be an important receptor for CysLTs, particularly for LTE4 : the CystLTs show relative potencies of LTE4 > LTC4 > LTD4 in stimulating GPR99-bearing cells and GPR99-deficient mice exhibit a dose-dependent loss of vascular permeability responses in skin to LTE4 but not to LTC4 or LTD4.
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