Renal clearance of acecainide following short and long term administration ranges from 2.08?.36 mL / min / kg to 3.28?.52 mL / min / kg in healthy people.
12.
The mean renal clearance for trospium ( 29 L / hour ) is 4-fold higher than average glomerular filtration rate, indicating that active tubular secretion is a major route of elimination for trospium.
13.
Salicylates are excreted mainly by the kidneys as salicyluric acid ( 75 % ), free salicylic acid ( 10 % ), salicylic phenol ( 10 % ), and acyl glucuronides ( 5 % ), gentisic acid ( < 1 % ), and urinary pH . A 10-to 20-fold increase in renal clearance occurs when urine pH is increased from 5 to 8.
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