11. 3D structure of ribonuclease S, drawn as the frontispiece for an early review on protein structure 12. RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. 13. This protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. 14. Eosinophil cationic protein and the sequence related eosinophil-derived neurotoxin are both members of the ribonuclease a superfamily. 15. They encode four protein domains in the following order : protease, integrase, reverse transcriptase, and ribonuclease H. 16. It can be inhibited by ribonuclease inhibitor protein, by heavy metal ions, and by uridine-vanadate complexes. 17. The experiment confirmed that converting the two amino acids to non-functional counterparts did inhibit ECP s ribonuclease activity. 18. The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme ( RNAseH2 ). 19. Abnormalities observed include hyperactivity of Ribonuclease L, a protein activated by IFN, and hyperactivity of NF-?B. 20. They encode at least four protein domains in the order : protease, reverse transcriptase, ribonuclease H, and integrase.
