This is due to the failure of the Hertwig epithelial root sheath which maps the shape of the forming tooth roots during active differentiation.
12.
During root formation the inner layers of epithelium disappear and only the basal layers are left creating Hertwig's Epithelial Root Sheath ( HERS ).
13.
When BMP4 is expressed ectopically, within transgenic mice the hair follicle outer root sheath ( ORS ) the proliferation of the cell matrix is inhibited.
14.
The root sheath eventually disintegrates with the periodontal ligament, but residual pieces that do not completely disappear are seen as epithelial cell rests of Malassez ( ERM ).
15.
The cementoblasts differentiate from follicular cells, which can only reach the surface of the tooth's root once Hertwig's Epithelial Root Sheath ( HERS ) has begun to deteriorate.
16.
The hot petrolatum used with the iron was thought to cause a chronic inflammation around the upper segment of the hair follicle leading to degeneration of the external root sheath.
17.
The living parts of hair ( hair follicle, hair root, root sheath, and sebaceous gland ) are beneath the skin, while the actual hair shaft which emerges ( the cuticle which covers the cortex and medulla ) has no living processes.
18.
Keratin 17 is expressed in several epithelial structures, most notably in sebaceous glands, the outer root sheath of hair follicles, and the nail bed; its expression correlates well to the clinical phenotypic expression of both steatocystoma multiplex and pachyonychia congenita type 2.
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