This is because the selection pressure of incomplete suppression of viral replication in the presence of drug therapy causes the more drug sensitive strains to be selectively inhibited.
12.
Following oral administration, the fecal concentration of vancomycin is around 500 �g / ml ( sensitive strains of " C . difficile " have a mean inhibitory concentration of d " 2 �g / ml)
13.
An example might be a close contact of a patient known to have a fully sensitive strain of tuberculosis : in this case, it is acceptable to use 2HRZ / 4HR ( omitting EMB and STM ) in the expectation that their strain will be INH susceptible also.
14.
That said, most patients who relapse do so with a fully sensitive strain and it is possible that these patients have not relapsed, but have instead been re-infected; these patients can be re-treated with the same regimen as before ( no drugs need to be added to the regimen and the duration need not be any longer ).
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